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Synthesis and evaluation of 9-deoxy analogues of (-)-thysanone, an inhibitor of HRV 3C protease.
- Source :
-
European journal of medicinal chemistry [Eur J Med Chem] 2014 Nov 24; Vol. 87, pp. 220-7. Date of Electronic Publication: 2014 Sep 22. - Publication Year :
- 2014
-
Abstract
- 9-Deoxy analogues of the HRV 3C protease inhibitor (-)-thysanone display better inhibitory properties than the natural product, inferring the C9-OH hinders binding to the enzyme.<br /> (Copyright © 2014 Elsevier Masson SAS. All rights reserved.)
- Subjects :
- 3C Viral Proteases
Benzopyrans chemistry
Chemistry Techniques, Synthetic
Cysteine Endopeptidases metabolism
Naphthoquinones chemistry
Protease Inhibitors chemistry
Viral Proteins metabolism
Benzopyrans chemical synthesis
Benzopyrans pharmacology
Drug Design
Naphthoquinones chemical synthesis
Naphthoquinones pharmacology
Protease Inhibitors chemical synthesis
Protease Inhibitors pharmacology
Rhinovirus enzymology
Viral Proteins antagonists & inhibitors
Subjects
Details
- Language :
- English
- ISSN :
- 1768-3254
- Volume :
- 87
- Database :
- MEDLINE
- Journal :
- European journal of medicinal chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 25259514
- Full Text :
- https://doi.org/10.1016/j.ejmech.2014.09.063