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The path of least resistance: aggressive or moderate treatment?

The path of least resistance: aggressive or moderate treatment?

Authors :
Kouyos RD
Metcalf CJ
Birger R
Klein EY
Abel zur Wiesch P
Ankomah P
Arinaminpathy N
Bogich TL
Bonhoeffer S
Brower C
Chi-Johnston G
Cohen T
Day T
Greenhouse B
Huijben S
Metlay J
Mideo N
Pollitt LC
Read AF
Smith DL
Standley C
Wale N
Grenfell B
Source :
Proceedings. Biological sciences [Proc Biol Sci] 2014 Nov 07; Vol. 281 (1794), pp. 20140566.
Publication Year :
2014

Abstract

The evolution of resistance to antimicrobial chemotherapy is a major and growing cause of human mortality and morbidity. Comparatively little attention has been paid to how different patient treatment strategies shape the evolution of resistance. In particular, it is not clear whether treating individual patients aggressively with high drug dosages and long treatment durations, or moderately with low dosages and short durations can better prevent the evolution and spread of drug resistance. Here, we summarize the very limited available empirical evidence across different pathogens and provide a conceptual framework describing the information required to effectively manage drug pressure to minimize resistance evolution.<br /> (© 2014 The Author(s) Published by the Royal Society. All rights reserved.)

Details

Language :
English
ISSN :
1471-2954
Volume :
281
Issue :
1794
Database :
MEDLINE
Journal :
Proceedings. Biological sciences
Publication Type :
Academic Journal
Accession number :
25253451
Full Text :
https://doi.org/10.1098/rspb.2014.0566