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Metabolic changes during medical treatment of endometriosis: nafarelin acetate versus danazol.
- Source :
-
American journal of obstetrics and gynecology [Am J Obstet Gynecol] 1989 Jun; Vol. 160 (6), pp. 1454-9; discussion 1459-61. - Publication Year :
- 1989
-
Abstract
- In this double-blind study of changes in plasma lipid and lipoprotein concentrations during 6-month medical treatment of endometriosis, 53 patients were randomly assigned to one of four treatment schedules: danazol, 800 mg/day (n = 10); danazol, 600 mg/day (n = 8); intranasal nafarelin acetate, 800 micrograms/day (n = 10); or intranasal nafarelin acetate, 400 micrograms/day (n = 25). Plasma levels of triglycerides, cholesterol, and low-density lipoprotein, very low-density lipoprotein, and high-density lipoprotein cholesterol fractions were obtained before, during, and 1 month after treatment. High-density lipoprotein2 and high-density lipoprotein3 cholesterol concentrations were measured in selected patients. Body weight was also followed. The drugs were equally effective in achieving symptomatic relief and laparoscopically demonstrated resolution of endometriosis but differed significantly in their effects on lipid concentrations. Nafarelin acetate had no adverse effects on serum lipoprotein concentrations, whereas danazol significantly decreased high-density lipoprotein cholesterol (p less than 0.01), as well as the high-density lipoprotein2 subfraction (p less than 0.05), and increased low-density lipoprotein cholesterol (p less than 0.01). Danazol significantly increased body weight (p less than 0.01), whereas nafarelin did not.
- Subjects :
- Administration, Intranasal
Adult
Cholesterol blood
Clinical Trials as Topic
Danazol administration & dosage
Double-Blind Method
Endometriosis blood
Endometriosis metabolism
Female
Genital Neoplasms, Female blood
Genital Neoplasms, Female metabolism
Gonadotropin-Releasing Hormone administration & dosage
Gonadotropin-Releasing Hormone therapeutic use
Humans
Infertility, Female etiology
Lipoproteins, HDL blood
Lipoproteins, LDL blood
Nafarelin
Pregnancy
Random Allocation
Time Factors
Danazol therapeutic use
Endometriosis drug therapy
Genital Neoplasms, Female drug therapy
Gonadotropin-Releasing Hormone analogs & derivatives
Lipids blood
Pregnadienes therapeutic use
Subjects
Details
- Language :
- English
- ISSN :
- 0002-9378
- Volume :
- 160
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- American journal of obstetrics and gynecology
- Publication Type :
- Academic Journal
- Accession number :
- 2525337
- Full Text :
- https://doi.org/10.1016/0002-9378(89)90870-3