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The genome of Coxiella burnetii Z3055, a clone linked to the Netherlands Q fever outbreaks, provides evidence for the role of drift in the emergence of epidemic clones.
- Source :
-
Comparative immunology, microbiology and infectious diseases [Comp Immunol Microbiol Infect Dis] 2014 Dec; Vol. 37 (5-6), pp. 281-8. Date of Electronic Publication: 2014 Sep 16. - Publication Year :
- 2014
-
Abstract
- Coxiella burnetii is a pathogen causing Q fever. The aim of our work was to study Z3055, a strain that is genotypically related to the strain causing the Netherlands outbreak. We compared Z3055 to 5 other completed genomes available in GenBank. We calculated the blast score ratio (BSR) to analyze genetic differences among the strains. The ratio core genome/pangenome was 98% likely other bacteria with closed pangenomes. Differences between Z3055 and the reference NMI consisted only of point mutations and insertion/deletion (INDELs). Non-synonymous mutations significantly increased in genes coding for membrane proteins (16/156 vs 103/1757, bilateral Chi(2) test, p<0.05), ankyrin repeat domains containing proteins (2/9 vs 117/1904, bilateral Chi(2) test, p<0.05), transcription factors (7/53 vs 112/1860, bilateral Chi(2) test, p<0.05) and translation proteins (15/144 vs 109/1655, bilateral Chi(2) test, p<0.05). The evolution of this strain may have been driven by mutations in critical genes.<br /> (Copyright © 2014 Elsevier Ltd. All rights reserved.)
- Subjects :
- Ankyrin Repeat genetics
Bacterial Proteins metabolism
Clone Cells
Coxiella burnetii classification
Coxiella burnetii pathogenicity
Genotype
Humans
INDEL Mutation
Membrane Proteins genetics
Membrane Proteins metabolism
Netherlands epidemiology
Phylogeny
Point Mutation
Q Fever microbiology
Q Fever pathology
Transcription Factors genetics
Transcription Factors metabolism
Bacterial Proteins genetics
Coxiella burnetii genetics
Disease Outbreaks
Genetic Drift
Genome, Bacterial
Q Fever epidemiology
Subjects
Details
- Language :
- English
- ISSN :
- 1878-1667
- Volume :
- 37
- Issue :
- 5-6
- Database :
- MEDLINE
- Journal :
- Comparative immunology, microbiology and infectious diseases
- Publication Type :
- Academic Journal
- Accession number :
- 25249233
- Full Text :
- https://doi.org/10.1016/j.cimid.2014.08.003