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High-risk plaque in the superficial femoral artery of people with peripheral artery disease: prevalence and associated clinical characteristics.
- Source :
-
Atherosclerosis [Atherosclerosis] 2014 Nov; Vol. 237 (1), pp. 169-76. Date of Electronic Publication: 2014 Sep 02. - Publication Year :
- 2014
-
Abstract
- Objective: We used magnetic resonance imaging (MRI) to study the prevalence and associated clinical characteristics of high-risk plaque (defined as presence of lipid-rich necrotic core [LRNC] and intraplaque hemorrhage) in the superficial femoral arteries (SFA) among people with peripheral artery disease (PAD).<br />Background: The prevalence and clinical characteristics associated with high-risk plaque in the SFA are unknown.<br />Methods: Three-hundred-three participants with PAD underwent MRI of the proximal SFA using a 1.5 T S platform. Twelve contiguous 2.5 mm cross-sectional images were obtained.<br />Results: LRNC was present in 68 (22.4%) participants. Only one had intra-plaque hemorrhage. After adjusting for age and sex, smoking prevalence was higher among adults with LRNC than among those without LRNC (35.9% vs. 21.4%, p = 0.02). Among participants with vs. without LRNC there were no differences in mean percent lumen area (31% vs. 33%, p = 0.42), normalized mean wall area (0.71 vs. 0.70, p = 0.67) or maximum wall area (0.96 vs. 0.92, p = 0.54) in the SFA. Among participants with LRNC, cross-sectional images containing LRNC had a smaller percent lumen area (33% ± 1% vs. 39% ± 1%, p < 0.001), greater normalized mean wall thickness (0.25 ± 0.01 vs. 0.22 ± 0.01, p < 0.001), and greater normalized maximum wall thickness (0.41 ± 0.01 vs. 0.31 ± 0.01, p < 0.001), compared to cross-sectional images without LRNC.<br />Conclusions: Fewer than 25% of adults with PAD had high-risk plaque in the proximal SFA using MRI. Smoking was the only clinical characteristic associated with presence of LRNC. Further study is needed to determine the prognostic significance of LRNC in the SFA.<br />Clinical Trial Registration-Url: http://www.clinicaltrials.gov. Unique identifier: NCT00520312.<br /> (Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.)
- Subjects :
- Aged
Ankle Brachial Index
Cohort Studies
Comorbidity
Female
Humans
Lipids chemistry
Magnetic Resonance Imaging
Male
Middle Aged
Necrosis
Oscillometry
Prevalence
Prospective Studies
Random Allocation
Smoking
Treatment Outcome
Walking
Femoral Artery pathology
Peripheral Arterial Disease diagnosis
Peripheral Arterial Disease pathology
Plaque, Atherosclerotic diagnosis
Plaque, Atherosclerotic pathology
Subjects
Details
- Language :
- English
- ISSN :
- 1879-1484
- Volume :
- 237
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Atherosclerosis
- Publication Type :
- Academic Journal
- Accession number :
- 25240112
- Full Text :
- https://doi.org/10.1016/j.atherosclerosis.2014.08.034