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[A rare cause of pulmonary opacities: Lung localization of Waldenström's macroglobulinemia].
- Source :
-
Revue des maladies respiratoires [Rev Mal Respir] 2014 Sep; Vol. 31 (7), pp. 632-5. Date of Electronic Publication: 2013 Dec 30. - Publication Year :
- 2014
-
Abstract
- Introduction: Pulmonary localized forms of Waldenström's macroglobulinemia are rare.<br />Case Report: We report the observation of a 71-year-old woman with chronic cough and persisting alveolar opacities after several courses of antibiotics. Physical examination was unremarkable. Protein electrophoresis identified a monoclonal IgM in the serum. The lymphocyte immunophenotyping from the bronchoalveolar lavage was consistent with a B-cell lymphoma and Waldenström's macroglobulinemia was confirmed by the bone marrow biopsy. Chemotherapy with a combination of rituximab, fludarabine and cyclophosphamide improved the patient's symptoms and caused the pulmonary opacities to resolve. We discuss the various clinical and radiological pulmonary manifestations of this slowly progressive hematological condition.<br />Conclusion: Pulmonary manifestations of Waldenström's macroglobulinemia result in various clinical and radiological patterns. A serum protein electrophoresis should be performed in cases of pleuropulmonary opacities persisting despite antibiotics.<br /> (Copyright © 2013 SPLF. Published by Elsevier Masson SAS. All rights reserved.)
Details
- Language :
- French
- ISSN :
- 1776-2588
- Volume :
- 31
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- Revue des maladies respiratoires
- Publication Type :
- Academic Journal
- Accession number :
- 25239587
- Full Text :
- https://doi.org/10.1016/j.rmr.2013.10.648