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An Automated Process for a Sequential Heterocycle/Multicomponent Reaction: Multistep Continuous Flow Synthesis of 5-(Thiazol-2-yl)-3,4-Dihydropyrimidin-2( 1H )-ones.
- Source :
-
Journal of flow chemistry [J Flow Chem] 2011 Aug 25; Vol. 1 (1), pp. 28-31. - Publication Year :
- 2011
-
Abstract
- The first example of a sequential heterocycle formation/multicomponent reaction using an automated continuous flow microreactor assembly is reported. Consecutive Hantzsch thiazole synthesis, deketalization, and Biginelli multicomponent reaction provides rapid and efficient access to highly functionalized, pharmacologically significant 5-(thiazol-2-yl)-3,4-dihydropyrimidin-2( 1H )-ones without isolation of intermediates. These complex small molecules are generated in reaction times less than 15 min and in high yields (39-46%) over three continuous chemical steps.
Details
- Language :
- English
- ISSN :
- 2062-249X
- Volume :
- 1
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Journal of flow chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 25237558
- Full Text :
- https://doi.org/10.1556/jfchem.2011.00001