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Outcomes after liver transplantation for combined alcohol and hepatitis C virus infection.
- Source :
-
World journal of gastroenterology [World J Gastroenterol] 2014 Sep 14; Vol. 20 (34), pp. 11935-8. - Publication Year :
- 2014
-
Abstract
- Alcohol abuse and chronic hepatitis C virus (HCV) infection are two major causes of chronic liver disease in the United States. About 10%-15% of liver transplants performed in the United States are for patients with cirrhosis due to combined alcohol and HCV infection. Data on outcomes on graft and patient survival, HCV recurrence, and relapse of alcohol use comparing transplants in hepatitis C positive drinkers compared to alcohol abuse or hepatitis C alone are conflicting in the literature. Some studies report a slightly better overall outcome in patients who were transplanted for alcoholic cirrhosis vs those transplanted for HCV alone or for combined HCV and alcohol related cirrhosis. However, some other studies do not support these observations. However, most studies are limited to a retrospective design or small sample size. Larger prospective multicenter studies are needed to better define the outcomes in hepatitis C drinkers.
- Subjects :
- Alcohol Abstinence
Alcohol Drinking adverse effects
Alcohol Drinking prevention & control
Graft Survival
Hepacivirus pathogenicity
Hepatitis C, Chronic diagnosis
Hepatitis C, Chronic mortality
Hepatitis, Alcoholic diagnosis
Hepatitis, Alcoholic mortality
Humans
Recurrence
Risk Factors
Time Factors
Treatment Outcome
Virus Activation
Waiting Lists mortality
Hepatitis C, Chronic surgery
Hepatitis, Alcoholic surgery
Liver Transplantation adverse effects
Liver Transplantation mortality
Subjects
Details
- Language :
- English
- ISSN :
- 2219-2840
- Volume :
- 20
- Issue :
- 34
- Database :
- MEDLINE
- Journal :
- World journal of gastroenterology
- Publication Type :
- Academic Journal
- Accession number :
- 25232228
- Full Text :
- https://doi.org/10.3748/wjg.v20.i34.11935