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Alcoholic hepatitis and concomitant hepatitis C virus infection.
- Source :
-
World journal of gastroenterology [World J Gastroenterol] 2014 Sep 14; Vol. 20 (34), pp. 11929-34. - Publication Year :
- 2014
-
Abstract
- Hepatitis C virus (HCV) infection and alcohol abuse are two most important causes of chronic liver disease in the United States. Alcoholic hepatitis is a unique clinical syndrome among patients with chronic and active alcohol abuse with a potential for high short-term mortality. About 20% of patients presenting with alcoholic hepatitis have concomitant HCV infection. Mortality from alcoholic hepatitis is increased in the presence of concomitant hepatitis C due to synergistic interaction between HCV and alcohol in causing hepatocellular damage. Large prospective randomized studies are needed to develop guidelines on the use of corticosteroids among patients with alcoholic hepatitis and concomitant HCV infection. The impact of antiviral therapy on mortality and outcome in the setting of alcoholic hepatitis remains a novel area for future research.
- Subjects :
- Adrenal Cortex Hormones therapeutic use
Antiviral Agents therapeutic use
Comorbidity
Hepacivirus pathogenicity
Host-Pathogen Interactions
Humans
Prevalence
Risk Factors
Treatment Outcome
Hepatitis C diagnosis
Hepatitis C drug therapy
Hepatitis C mortality
Hepatitis, Alcoholic diagnosis
Hepatitis, Alcoholic drug therapy
Hepatitis, Alcoholic mortality
Subjects
Details
- Language :
- English
- ISSN :
- 2219-2840
- Volume :
- 20
- Issue :
- 34
- Database :
- MEDLINE
- Journal :
- World journal of gastroenterology
- Publication Type :
- Academic Journal
- Accession number :
- 25232227
- Full Text :
- https://doi.org/10.3748/wjg.v20.i34.11929