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Iron-catalyzed coupling of aryl sulfamates and aryl/vinyl tosylates with aryl Grignards.
- Source :
-
Organic letters [Org Lett] 2014 Oct 03; Vol. 16 (19), pp. 5080-3. Date of Electronic Publication: 2014 Sep 17. - Publication Year :
- 2014
-
Abstract
- The iron-catalyzed coupling of aryl sulfamates and tosylates with aryl Grignard reagents is reported for the first time. The methodology employs air-stable, low-cost FeF3·3H2O and the N-heterocyclic carbene ligand IPr·HCl as the preligand to form a long-lived catalyst upon treatment with aryl Grignards. The reaction provides a range of cross-coupled products in good-to-excellent yields. In contrast to previous reports with aryl chlorides, these reactions proceed with low levels of Grignard homocoupling regardless of the iron source.
Details
- Language :
- English
- ISSN :
- 1523-7052
- Volume :
- 16
- Issue :
- 19
- Database :
- MEDLINE
- Journal :
- Organic letters
- Publication Type :
- Academic Journal
- Accession number :
- 25230097
- Full Text :
- https://doi.org/10.1021/ol5024344