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Targeting dendritic cell function during systemic autoimmunity to restore tolerance.
- Source :
-
International journal of molecular sciences [Int J Mol Sci] 2014 Sep 16; Vol. 15 (9), pp. 16381-417. Date of Electronic Publication: 2014 Sep 16. - Publication Year :
- 2014
-
Abstract
- Systemic autoimmune diseases can damage nearly every tissue or cell type of the body. Although a great deal of progress has been made in understanding the pathogenesis of autoimmune diseases, current therapies have not been improved, remain unspecific and are associated with significant side effects. Because dendritic cells (DCs) play a major role in promoting immune tolerance against self-antigens (self-Ags), current efforts are focusing at generating new therapies based on the transfer of tolerogenic DCs (tolDCs) during autoimmunity. However, the feasibility of this approach during systemic autoimmunity has yet to be evaluated. TolDCs may ameliorate autoimmunity mainly by restoring T cell tolerance and, thus, indirectly modulating autoantibody development. In vitro induction of tolDCs loaded with immunodominant self-Ags and subsequent cell transfer to patients would be a specific new therapy that will avoid systemic immunosuppression. Herein, we review recent approaches evaluating the potential of tolDCs for the treatment of systemic autoimmune disorders.
- Subjects :
- Anti-Inflammatory Agents pharmacology
Anti-Inflammatory Agents therapeutic use
Autoimmune Diseases drug therapy
Autoimmune Diseases metabolism
B-Lymphocytes immunology
Cholecalciferol therapeutic use
Dendritic Cells drug effects
Dendritic Cells metabolism
Granulocyte-Macrophage Colony-Stimulating Factor therapeutic use
Humans
Immune Tolerance
Nitriles therapeutic use
Sulfones therapeutic use
T-Lymphocytes immunology
Autoimmune Diseases pathology
Dendritic Cells immunology
Subjects
Details
- Language :
- English
- ISSN :
- 1422-0067
- Volume :
- 15
- Issue :
- 9
- Database :
- MEDLINE
- Journal :
- International journal of molecular sciences
- Publication Type :
- Academic Journal
- Accession number :
- 25229821
- Full Text :
- https://doi.org/10.3390/ijms150916381