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Influenza vaccine effectiveness estimates for Western Australia during a period of vaccine and virus strain stability, 2010 to 2012.
- Source :
-
Vaccine [Vaccine] 2014 Oct 29; Vol. 32 (47), pp. 6312-8. Date of Electronic Publication: 2014 Sep 16. - Publication Year :
- 2014
-
Abstract
- During 2010-2012 the strain composition of the influenza vaccine in the Southern Hemisphere did not change, but the circulating virus type/subtype did. We pooled data for these years from the Western Australian sentinel medical practice surveillance system for influenza to estimate vaccine effectiveness (VE) by influenza virus type and subtype. A case test-negative design was used with VE estimated as (1-odds ratio)×100%. There were 2182 patients included in the analysis across the 3 years studied. The predominant subtype was A/H1pdm09 in 2010 and 2011, and A/H3 in 2012. The overall adjusted VE estimate against all influenza for 2010-2012 was 51% (95% CI: 36, 63). Estimates were highest against A/H1pdm09 at 74% (95% CI: 47, 87), followed by 56% (95% CI: 33, 71) for influenza B and lowest against A/H3 at 39% (95% CI: 13, 57). When analyses were restricted to compare influenza-positive patients with patients who tested positive for a non-influenza virus, overall adjusted VE was 59% (95% CI: 39, 72). These results suggest moderate protection against influenza by vaccination in Western Australia over the period 2010-2012, and are consistent with findings from other settings.<br /> (Copyright © 2014 Elsevier Ltd. All rights reserved.)
- Subjects :
- Adolescent
Adult
Aged
Aged, 80 and over
Case-Control Studies
Child
Child, Preschool
Female
Humans
Infant
Infant, Newborn
Influenza A Virus, H1N1 Subtype
Influenza A Virus, H3N2 Subtype
Influenza B virus
Influenza Vaccines immunology
Influenza, Human epidemiology
Influenza, Human virology
Male
Middle Aged
Odds Ratio
Western Australia epidemiology
Young Adult
Influenza Vaccines therapeutic use
Influenza, Human prevention & control
Sentinel Surveillance
Subjects
Details
- Language :
- English
- ISSN :
- 1873-2518
- Volume :
- 32
- Issue :
- 47
- Database :
- MEDLINE
- Journal :
- Vaccine
- Publication Type :
- Academic Journal
- Accession number :
- 25223268
- Full Text :
- https://doi.org/10.1016/j.vaccine.2014.08.066