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Chronic nicotine use blocks haloperidol-induced increase in striatal D2-dopamine receptor density.
- Source :
-
Biochemical and biophysical research communications [Biochem Biophys Res Commun] 1989 Feb 28; Vol. 159 (1), pp. 48-52. - Publication Year :
- 1989
-
Abstract
- Epidemiologic studies have suggested a positive association in man between nicotine use and the incidence of tardive dyskinesia, a disease characterized by dopaminergic supersensitivity after chronic neuroleptic therapy. In rats, repeated administration of neuroleptics results into dopaminergic supersensitivity and increased density of striatal D2-dopamine receptors. We investigated the effects of 6-week continuous nicotine intake on the neuroleptic (haloperidol)-induced increase in murine striatal D2-dopamine receptor density. Contrary to expectations, our data show that nicotine blocked the increase in D2-dopamine receptor density after neuroleptic administration.
Details
- Language :
- English
- ISSN :
- 0006-291X
- Volume :
- 159
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Biochemical and biophysical research communications
- Publication Type :
- Academic Journal
- Accession number :
- 2522303
- Full Text :
- https://doi.org/10.1016/0006-291x(89)92402-9