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The role of gene regulatory factors in the evolutionary history of humans.
- Source :
-
Current opinion in genetics & development [Curr Opin Genet Dev] 2014 Dec; Vol. 29, pp. 60-7. Date of Electronic Publication: 2014 Sep 15. - Publication Year :
- 2014
-
Abstract
- Deciphering the molecular basis of how modern human phenotypes have evolved is one of the most fascinating challenges in biology. Here, we will focus on the roles of gene regulatory factors (GRFs), in particular transcription factors (TFs) and long non-coding RNAs (lncRNAs) during human evolution. We will present examples of TFs and lncRNAs that have changed or show signs of positive selection in humans compared to chimpanzees, in modern humans compared to archaic humans, or within modern human populations. On the basis of current knowledge about the functions of these GRF genes, we speculate that they have been involved in speciation as well as in shaping phenotypes such as brain functions, skeletal morphology, and metabolic processes.<br /> (Copyright © 2014 Elsevier Ltd. All rights reserved.)
Details
- Language :
- English
- ISSN :
- 1879-0380
- Volume :
- 29
- Database :
- MEDLINE
- Journal :
- Current opinion in genetics & development
- Publication Type :
- Academic Journal
- Accession number :
- 25215414
- Full Text :
- https://doi.org/10.1016/j.gde.2014.08.007