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The ALDH7A1 genetic polymorphisms contribute to development of esophageal squamous cell carcinoma.
- Source :
-
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine [Tumour Biol] 2014 Dec; Vol. 35 (12), pp. 12665-70. Date of Electronic Publication: 2014 Sep 12. - Publication Year :
- 2014
-
Abstract
- Although the entire etiology of esophageal squamous cell carcinoma (ESCC) is still unclear, alcohol drinking has been identified as a major environmental risk factor. The aldehyde dehydrogenase (ALDH) superfamily members are major enzymes involved in the alcohol-metabolizing pathways. Accumulating evidences demonstrated that ALDH7A1, one of ALDH superfamily members, degrades and detoxifies acetaldehyde generated by alcohol metabolism and have been associated with development and prognosis of multiple cancers. However, it is still unknown if ALDH7A1 single nucleotide polymorphisms (SNPs) contribute to ESCC susceptibility. In this study, we examined the association between sixteen ALDH7A1 SNPs and risk of developing ESCC. Genotypes were determined in 2,098 ESCC patients and 2,150 controls (three independent hospital-based case-control sets from different regions of China). Odds ratios (ORs) and 95 % confidence intervals (CIs) were estimated by logistic regression. Our data demonstrated that only the ALDH7A1 rs13182402 SNP confer susceptibility to ESCC (For AG genotype, OR = 0.75, 95 % CI = 0.66-0.91, P = 4.8 × 10(-6); for GG genotype, OR = 0.59, 95 % CI = 0.41-0.88, P = 0.003). These results are consistent to the biological functions of ALDH7A1 during alcohol metabolism and carcinogenesis.
- Subjects :
- Adult
Aged
Alleles
Case-Control Studies
China
Esophageal Squamous Cell Carcinoma
Female
Gene Frequency
Genetic Predisposition to Disease
Genotype
Humans
Male
Middle Aged
Odds Ratio
Polymorphism, Single Nucleotide
Risk Factors
Aldehyde Dehydrogenase genetics
Carcinoma, Squamous Cell genetics
Esophageal Neoplasms genetics
Polymorphism, Genetic
Subjects
Details
- Language :
- English
- ISSN :
- 1423-0380
- Volume :
- 35
- Issue :
- 12
- Database :
- MEDLINE
- Journal :
- Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine
- Publication Type :
- Academic Journal
- Accession number :
- 25213698
- Full Text :
- https://doi.org/10.1007/s13277-014-2590-9