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Frequency and phenotype of B cell subpopulations in young and aged HIV-1 infected patients receiving ART.
- Source :
-
Retrovirology [Retrovirology] 2014 Sep 11; Vol. 11, pp. 76. Date of Electronic Publication: 2014 Sep 11. - Publication Year :
- 2014
-
Abstract
- Background: Aged individuals respond poorly to vaccination and have a higher risk of contracting infections in comparison to younger individuals; whether age impacts on the composition and function of B cell subpopulations relevant for immune responses is still controversial. It is also not known whether increased age during HIV-1 infection further synergizes with the virus to alter B cell subpopulations. In view of the increased number of HIV-1 infected patients living to high age as a result of anti-retroviral treatment this is an important issue to clarify.<br />Results: In this work we evaluated the distribution of B cell subpopulations in young and aged healthy individuals and HIV-1 infected patients, treated and naïve to treatment. B cell populations were characterized for the expression of inhibitory molecules (PD-1 and FcRL4) and activation markers (CD25 and CD69); the capacity of B cells to respond to activation signals through up-regulation of IL-6 expression was also evaluated. Increased frequencies of activated and tissue-like memory B cells occurring during HIV-1 infection are corrected by prolonged ART therapy. Our findings also reveal that, in spite of prolonged treatment, resting memory B cells in both young and aged HIV-1 infected patients are reduced in number, and all memory B cell subsets show a low level of expression of the activation marker CD25.<br />Conclusions: The results of our study show that resting memory B cells in ART-treated young and aged HIV-1 infected patients are reduced in number and memory B cell subsets exhibit low expression of the activation marker CD25. Aging per se in the HIV-1 infected population does not worsen impairments initiated by HIV-1 in the memory B cell populations of young individuals.
- Subjects :
- Adult
Age Factors
Aged
Aged, 80 and over
Antigens, CD analysis
Antigens, Differentiation, T-Lymphocyte analysis
HIV Infections drug therapy
HIV Infections virology
Humans
Interleukin-2 Receptor alpha Subunit analysis
Interleukin-6 biosynthesis
Lectins, C-Type analysis
Middle Aged
Phenotype
Aging immunology
Anti-HIV Agents therapeutic use
B-Lymphocyte Subsets immunology
HIV Infections immunology
HIV-1
Subjects
Details
- Language :
- English
- ISSN :
- 1742-4690
- Volume :
- 11
- Database :
- MEDLINE
- Journal :
- Retrovirology
- Publication Type :
- Academic Journal
- Accession number :
- 25213015
- Full Text :
- https://doi.org/10.1186/s12977-014-0076-x