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Circadian rhythm reprogramming during lung inflammation.
- Source :
-
Nature communications [Nat Commun] 2014 Sep 11; Vol. 5, pp. 4753. Date of Electronic Publication: 2014 Sep 11. - Publication Year :
- 2014
-
Abstract
- Circadian rhythms are known to regulate immune responses in healthy animals, but it is unclear whether they persist during acute illnesses where clock gene expression is disrupted by systemic inflammation. Here we use a genome-wide approach to investigate circadian gene and metabolite expression in the lungs of endotoxemic mice and find that novel cellular and molecular circadian rhythms are elicited in this setting. The endotoxin-specific circadian programme exhibits unique features, including a divergent group of rhythmic genes and metabolites compared with the basal state and a distinct periodicity and phase distribution. At the cellular level, endotoxin treatment also alters circadian rhythms of leukocyte counts within the lung in a bmal1-dependent manner, such that granulocytes rather than lymphocytes become the dominant oscillating cell type. Our results show that inflammation produces a complex re-organization of cellular and molecular circadian rhythms that are relevant to early events in lung injury.
- Subjects :
- Animals
CLOCK Proteins immunology
CLOCK Proteins metabolism
Circadian Rhythm immunology
Circadian Rhythm Signaling Peptides and Proteins genetics
Circadian Rhythm Signaling Peptides and Proteins immunology
Circadian Rhythm Signaling Peptides and Proteins metabolism
Endotoxins toxicity
Gene Expression Regulation
Granulocytes immunology
Leukocyte Count
Lung immunology
Lymphocytes immunology
Mice
Pneumonia chemically induced
Pneumonia metabolism
CLOCK Proteins genetics
Circadian Rhythm genetics
Lung metabolism
Pneumonia genetics
RNA, Messenger metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 2041-1723
- Volume :
- 5
- Database :
- MEDLINE
- Journal :
- Nature communications
- Publication Type :
- Academic Journal
- Accession number :
- 25208554
- Full Text :
- https://doi.org/10.1038/ncomms5753