Casein kinase 1 and Wnt/β-catenin signaling.

Authors :: Cruciat CM
Source :: Current opinion in cell biology [Curr Opin Cell Biol] 2014 Dec; Vol. 31, pp. 46-55. Date of Electronic Publication: 2014 Sep 15.
Publication Year :: 2014
Abstract: Casein kinase 1 (CK1) members play a critical and evolutionary conserved role in Wnt/β-catenin signaling. They phosphorylate several pathway components and exert a dual function, acting as both Wnt activators and Wnt inhibitors. Recent discoveries suggest that CK1 members act in a coordinated manner to regulate early responses to Wnt and notably that their enzymatic activity is regulated. Here, I provide a brief update of CK1 function and regulation in Wnt/β-catenin signaling.<br /> (Copyright © 2014 Elsevier Ltd. All rights reserved.)