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Forazoline A: marine-derived polyketide with antifungal in vivo efficacy.
- Source :
-
Angewandte Chemie (International ed. in English) [Angew Chem Int Ed Engl] 2014 Oct 20; Vol. 53 (43), pp. 11583-6. Date of Electronic Publication: 2014 Sep 04. - Publication Year :
- 2014
-
Abstract
- Forazoline A, a novel antifungal polyketide with in vivo efficacy against Candida albicans, was discovered using LCMS-based metabolomics to investigate marine-invertebrate-associated bacteria. Forazoline A had a highly unusual and unprecedented skeleton. Acquisition of (13)C-(13)C gCOSY and (13)C-(15)N HMQC NMR data provided the direct carbon-carbon and carbon-nitrogen connectivity, respectively. This approach represents the first example of determining direct (13)C-(15)N connectivity for a natural product. Using yeast chemical genomics, we propose that forazoline A operated through a new mechanism of action with a phenotypic outcome of disrupting membrane integrity.<br /> (© 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.)
- Subjects :
- Animals
Antifungal Agents isolation & purification
Candida albicans drug effects
Carbon-13 Magnetic Resonance Spectroscopy
Magnetic Resonance Spectroscopy
Marine Biology
Mass Spectrometry
Mice
Microbial Sensitivity Tests
Molecular Structure
Polyketides isolation & purification
Antifungal Agents pharmacology
Bacteria chemistry
Polyketides pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 1521-3773
- Volume :
- 53
- Issue :
- 43
- Database :
- MEDLINE
- Journal :
- Angewandte Chemie (International ed. in English)
- Publication Type :
- Academic Journal
- Accession number :
- 25197007
- Full Text :
- https://doi.org/10.1002/anie.201405990