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Outcome of allogeneic hematopoietic stem cell transplantation for acute myeloid leukemia patients with central nervous system involvement.
- Source :
-
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation [Biol Blood Marrow Transplant] 2014 Dec; Vol. 20 (12), pp. 2029-33. Date of Electronic Publication: 2014 Sep 06. - Publication Year :
- 2014
-
Abstract
- Central nervous system (CNS) involvement in adult acute myeloid leukemia (AML) is rare and associated with poor outcomes. Therefore, CNS involvement in AML is an indicator for allogeneic hematopoietic stem cell transplantation (allo-HSCT). However, the impact of CNS involvement in AML on the outcome of allo-HSCT remains unclear. We performed a large-scale nationwide retrospective analysis to elucidate the outcomes of allo-HSCT on AML with CNS involvement (CNS+AML). Clinical data were collected from a registry database of the Japan Society for Hematopoietic Cell Transplantation. CNS involvement was defined as the infiltration of leukemia cells into the CNS or myeloid sarcoma in the CNS identified at any time from diagnosis to transplantation. One hundred fifty-seven patients with CNS+AML underwent allo-HSCT between 2006 and 2011. The estimated overall survival, cumulative incidence of relapse and nonrelapse mortality at 2 years for CNS+AML (51.2%, 30.2%, and 14.5%, respectively) were comparable with those for AML without CNS involvement (48.6%, 27.4%, and 22.0%, respectively). Univariate and multivariate analyses indicated that the development of chronic graft-versus-host disease, disease status, and cytogenetic risk category were independent prognostic factors for overall survival for CNS+AML. These results suggest that allo-HSCT may improve outcomes in patients with CNS+AML.<br /> (Copyright © 2014 American Society for Blood and Marrow Transplantation. Published by Elsevier Inc. All rights reserved.)
- Subjects :
- Adolescent
Adult
Aged
Aged, 80 and over
Allografts
Central Nervous System Neoplasms diagnosis
Chronic Disease
Disease-Free Survival
Female
Graft vs Host Disease etiology
Graft vs Host Disease mortality
Graft vs Host Disease therapy
Humans
Japan epidemiology
Leukemia, Myeloid, Acute diagnosis
Male
Middle Aged
Recurrence
Retrospective Studies
Sarcoma, Myeloid diagnosis
Sarcoma, Myeloid metabolism
Sarcoma, Myeloid therapy
Survival Rate
Central Nervous System Neoplasms mortality
Central Nervous System Neoplasms therapy
Hematopoietic Stem Cell Transplantation
Leukemia, Myeloid, Acute mortality
Leukemia, Myeloid, Acute therapy
Subjects
Details
- Language :
- English
- ISSN :
- 1523-6536
- Volume :
- 20
- Issue :
- 12
- Database :
- MEDLINE
- Journal :
- Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation
- Publication Type :
- Academic Journal
- Accession number :
- 25196856
- Full Text :
- https://doi.org/10.1016/j.bbmt.2014.09.001