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Multi-targeted molecular therapeutic approach in aggressive neuroblastoma: the effect of Focal Adhesion Kinase-Src-Paxillin system.
- Source :
-
Expert opinion on therapeutic targets [Expert Opin Ther Targets] 2014 Dec; Vol. 18 (12), pp. 1395-406. Date of Electronic Publication: 2014 Sep 05. - Publication Year :
- 2014
-
Abstract
- Introduction: Nonreceptor tyrosine kinases play key roles in the integrin system. Located at the focal adhesions, they consist of large protein complexes through which the cytoskeleton connects to the extracellular matrix. The focal adhesion kinase (FAK)-Src-paxillin complex, a major mediator of the integrin pathway, contributes to cell migration and motility. Its overexpression is increased in children with advanced neuroblastoma (NB), one of the most common malignancies of childhood, with poor survival.<br />Areas Covered: We review the most recent data on FAK-Src-paxillin and their implications in NB, the molecular structure and the regulatory mechanisms of each molecule and their interactions and up-to-date information on their use as the newest biomarkers and their potential use as therapeutic targets in NB.<br />Expert Opinion: Based on the current literature, we hypothesize that combined and concurrent inhibition of the FAK-Src-Paxillin system may result in significant tumor suppression and prevention or delay of metastasis.
- Subjects :
- Animals
Antineoplastic Agents metabolism
Drug Resistance, Multiple drug effects
Drug Resistance, Multiple physiology
Drug Resistance, Neoplasm drug effects
Drug Resistance, Neoplasm physiology
Focal Adhesion Kinase 1 metabolism
Humans
Neuroblastoma metabolism
Paxillin metabolism
src-Family Kinases metabolism
Antineoplastic Agents administration & dosage
Focal Adhesion Kinase 1 antagonists & inhibitors
Molecular Targeted Therapy methods
Neuroblastoma drug therapy
Paxillin antagonists & inhibitors
src-Family Kinases antagonists & inhibitors
Subjects
Details
- Language :
- English
- ISSN :
- 1744-7631
- Volume :
- 18
- Issue :
- 12
- Database :
- MEDLINE
- Journal :
- Expert opinion on therapeutic targets
- Publication Type :
- Academic Journal
- Accession number :
- 25189706
- Full Text :
- https://doi.org/10.1517/14728222.2014.952280