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Targeting neuropeptide receptors for cancer imaging and therapy: perspectives with bombesin, neurotensin, and neuropeptide-Y receptors.
- Source :
-
Journal of nuclear medicine : official publication, Society of Nuclear Medicine [J Nucl Med] 2014 Oct; Vol. 55 (10), pp. 1650-7. Date of Electronic Publication: 2014 Sep 04. - Publication Year :
- 2014
-
Abstract
- Receptors for some regulatory peptides are highly expressed in tumors. Selective radiolabeled peptides can bind with high affinity and specificity to these receptors and exhibit favorable pharmacologic and pharmacokinetic properties, making them suitable agents for imaging or targeted therapy. The success encountered with radiolabeled somatostatin analogs is probably the first of a long list, as multiple peptide receptors are now recognized as potential targets. This review focuses on 3 neuropeptide receptor systems (bombesin, neurotensin, and neuropeptide-Y) that offer high potential in the field of nuclear oncology. The underlying biology of these peptide/receptor systems, their physiologic and pathologic roles, and their differential distribution in normal and tumoral tissues are described with emphasis on breast, prostate, and lung cancers. Radiolabeled analogs that selectively target these receptors are highlighted.<br /> (© 2014 by the Society of Nuclear Medicine and Molecular Imaging, Inc.)
- Subjects :
- Breast Neoplasms drug therapy
Female
Humans
Lung Neoplasms drug therapy
Male
Peptides chemistry
Positron-Emission Tomography methods
Prostatic Neoplasms drug therapy
Tomography, X-Ray Computed methods
Breast Neoplasms diagnosis
Lung Neoplasms diagnosis
Prostatic Neoplasms diagnosis
Receptors, Bombesin chemistry
Receptors, Neuropeptide Y chemistry
Receptors, Neurotensin chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 1535-5667
- Volume :
- 55
- Issue :
- 10
- Database :
- MEDLINE
- Journal :
- Journal of nuclear medicine : official publication, Society of Nuclear Medicine
- Publication Type :
- Academic Journal
- Accession number :
- 25189338
- Full Text :
- https://doi.org/10.2967/jnumed.114.142000