Surgical treatment of intrahepatic cholangiocarcinoma in the USA.

Authors :: Lubezky N
Facciuto M
Harimoto N
Schwartz ME
Florman SS
Source :: Journal of hepato-biliary-pancreatic sciences [J Hepatobiliary Pancreat Sci] 2015 Feb; Vol. 22 (2), pp. 124-30. Date of Electronic Publication: 2014 Sep 04.
Publication Year :: 2015
Abstract: Cholangiocarcinoma (CC) is a malignancy that arises from the epithelial cells of the biliary system (ductules as well as large ducts, and likely from progenitor cells, as well). Intrahepatic CC (ICC) is the second most common primary hepatic malignancy after hepatocellular carcinoma (HCC), and accounts for 10-15% of primary liver cancers. ICC differs from both extrahepatic and CC and HCC and has unique risk factors, histological features, genetic alterations and clinical outcomes. The natural history and results of surgical intervention are not well described as ICC is a relatively uncommon tumor, especially in the USA. This article reviews the literature relevant to the surgical management and outcome of patients with ICC in the USA.<br /> (© 2014 Japanese Society of Hepato-Biliary-Pancreatic Surgery.)