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Augmentation of resistance of mice to bacterial infection by a polysaccharide-peptidoglycan complex (PSPG) extracted from Lactobacillus casei.
- Source :
-
Biotherapy (Dordrecht, Netherlands) [Biotherapy] 1989; Vol. 1 (3), pp. 169-77. - Publication Year :
- 1989
-
Abstract
- A water-soluble polysaccharide-peptidoglycan complex (PSPG) was prepared from heat-killed Lactobacillus casei by digesting the bacteria with N-acetylmuramidase. The molecular weight of PSPG was over 30,000, and the polysaccharide portion of PSPG, its main component was composed of rhamnose, glucose, galactose, glucosamine and galactosamine. Mice pretreated intraperitoneally with PSPG survived after a lethal infection with Listeria monocytogenes or Pseudomonas aeruginosa. The growth of infecting bacteria (L. monocytogenes, P. aeruginosa, Salmonella typhimurium, Escherichia coli) in both the peritoneal cavity and the liver was inhibited markedly in the mice that had been treated with PSPG. It was suggested that macrophages may be the main effector for the anti-infectious effect of PSPG since treatment of mice with carrageenan, a selective macrophage blocker, markedly reduced the anti-infectious effect of PSPG.
- Subjects :
- Animals
Bacterial Infections immunology
Carrageenan
Escherichia coli Infections immunology
Escherichia coli Infections prevention & control
Female
Listeriosis immunology
Listeriosis prevention & control
Mice
Mice, Inbred BALB C
Peptidoglycan analysis
Peptidoglycan biosynthesis
Polysaccharides analysis
Polysaccharides biosynthesis
Pseudomonas Infections immunology
Pseudomonas Infections prevention & control
Salmonella Infections, Animal immunology
Salmonella Infections, Animal prevention & control
Salmonella typhimurium
Bacterial Infections prevention & control
Lacticaseibacillus casei metabolism
Peptidoglycan therapeutic use
Polysaccharides therapeutic use
Subjects
Details
- Language :
- English
- ISSN :
- 0921-299X
- Volume :
- 1
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Biotherapy (Dordrecht, Netherlands)
- Publication Type :
- Academic Journal
- Accession number :
- 2518375
- Full Text :
- https://doi.org/10.1007/BF02170886