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Spatiotemporally programmable surface engineered nanoparticles for effective anticancer drug delivery.
- Source :
-
Macromolecular bioscience [Macromol Biosci] 2014 Nov; Vol. 14 (11), pp. 1652-62. Date of Electronic Publication: 2014 Sep 02. - Publication Year :
- 2014
-
Abstract
- Surface engineered nanoparticles (NPs) are fabricated from polycaprolactone-polyethylenimine-folic acid (PCL-PEI-FA) and polycaprolactone-S-S-polyethylene glycol (PCL-S-S-PEG) copolymers. FESEM reveals the core-shell structure of these NPs of about 230 nm size. It is assumed that the inner cores of these NPs are composed of PCL, while the outer shells are adorned with PEG and folic acid, introducing a stealthy nature and specific targeting capability. Moreover, the disulfide bonds in the PCL-S-S-PEG copolymers provide a reduction-induced degradation characteristic in these NPs. Cell line experiments demonstrate the enhanced endocytosis and cytotoxicity of these NPs. Thus PCL-PEI-FA/PCL-S-S-PEG NPs could be a better candidate for the tumor specific delivery of hydrophobic drugs.<br /> (© 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.)
- Subjects :
- Cell Survival drug effects
Chromatography, Gel
Folic Acid chemistry
Folic Acid pharmacology
Humans
MCF-7 Cells
Nanoparticles ultrastructure
Paclitaxel pharmacology
Particle Size
Polyesters chemistry
Polyethylene Glycols chemistry
Polyethyleneimine chemistry
Polymers chemical synthesis
Polymers chemistry
Proton Magnetic Resonance Spectroscopy
Reference Standards
Spectrophotometry, Ultraviolet
Spectroscopy, Fourier Transform Infrared
Static Electricity
Surface Properties
Time Factors
Antineoplastic Agents pharmacology
Drug Delivery Systems
Nanoparticles chemistry
Nanotechnology methods
Subjects
Details
- Language :
- English
- ISSN :
- 1616-5195
- Volume :
- 14
- Issue :
- 11
- Database :
- MEDLINE
- Journal :
- Macromolecular bioscience
- Publication Type :
- Academic Journal
- Accession number :
- 25181029
- Full Text :
- https://doi.org/10.1002/mabi.201400228