Gd-encapsulated carbonaceous dots with efficient renal clearance for magnetic resonance imaging.

Authors :: Chen H
Wang GD
Tang W
Todd T
Zhen Z
Tsang C
Hekmatyar K
Cowger T
Hubbard R
Zhang W
Stickney J
Shen B
Xie J
Source :: Advanced materials (Deerfield Beach, Fla.) [Adv Mater] 2014 Oct 22; Vol. 26 (39), pp. 6761-6766. Date of Electronic Publication: 2014 Sep 01.
Publication Year :: 2014
Abstract: Nanoprobes for MRI and optical imaging are demonstrated. Gd@C-dots possess strong fluorescence and can effectively enhance signals on T1 -weighted MR images. The nanoprobes have low toxicity, and, despite a relatively large size, can be efficiently excreted by renal clearance from the host after systemic injection.<br /> (© 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.)

Subjects :: Animals
Capsules
Cell Line, Tumor
Cell Survival drug effects
Contrast Media chemistry
Contrast Media pharmacokinetics
Contrast Media toxicity
Drug Stability
Gadolinium pharmacokinetics
Gadolinium toxicity
Humans
Ligands
Mice
Oligopeptides chemistry
Carbon chemistry
Gadolinium chemistry
Kidney metabolism
Magnetic Resonance Imaging methods
Nanoparticles chemistry

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