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Serum concentrations of anthraquinones after intake of Folium Sennae and potential modulation on P-glycoprotein.
- Source :
-
Planta medica [Planta Med] 2014 Oct; Vol. 80 (15), pp. 1291-7. Date of Electronic Publication: 2014 Sep 01. - Publication Year :
- 2014
-
Abstract
- Folium Sennae (leaves of Cassia angustifolia or senna) is a laxative and a component in diets for weight control. It contains a variety of anthranoids such as sennosides, aloe-emodin, and rhein. In order to measure the serum concentrations of senna anthranoids, Sprague-Dawley rats were orally administered with single dose and multiple doses of Folium Sennae. The concentrations of anthranoids in serum were determined by HPLC method before and after hydrolysis with sulfatase and β-glucuronidase. The results showed that in the serum, aloe-emodin glucuronides and rhein glucuronides were the major metabolites. Traces of rhein free form were present transiently during the early phase, whereas the free form of aloe-emodin was not detected. We also evaluated the modulation effect of Folium Sennae on P-glycoprotein by using the LS 180 cell model which showed that it significantly inhibited P-glycoprotein by 16-46 %. In conclusion, senna anthranoids were rapidly and extensively metabolized to rhein glucuronides and aloe-emodin glucuronides in rats. Folium Sennae ingestion inhibited the efflux function of P-glycoprotein in the intestine.<br /> (Georg Thieme Verlag KG Stuttgart · New York.)
- Subjects :
- ATP Binding Cassette Transporter, Subfamily B antagonists & inhibitors
Administration, Oral
Animals
Anthraquinones metabolism
Cell Line, Tumor drug effects
Glucuronides blood
Glucuronides metabolism
Humans
Male
Plant Leaves
Plants, Medicinal chemistry
Rats, Sprague-Dawley
ATP Binding Cassette Transporter, Subfamily B blood
Anthraquinones blood
Senna Plant chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 1439-0221
- Volume :
- 80
- Issue :
- 15
- Database :
- MEDLINE
- Journal :
- Planta medica
- Publication Type :
- Academic Journal
- Accession number :
- 25177847
- Full Text :
- https://doi.org/10.1055/s-0034-1383040