Back to Search
Start Over
Increased risk of urinary tract cancer in ESRD patients associated with usage of Chinese herbal products suspected of containing aristolochic acid.
- Source :
-
PloS one [PLoS One] 2014 Aug 29; Vol. 9 (8), pp. e105218. Date of Electronic Publication: 2014 Aug 29 (Print Publication: 2014). - Publication Year :
- 2014
-
Abstract
- Introduction: Both end-stage renal disease (ESRD) and urothelial cancer (UC) are associated with the consumption of Chinese herbal products containing aristolochic acid (AA) by the general population. The objective of this study was to determine the risk of UC associated with AA-related Chinese herbal products among ESRD patients.<br />Methods: We conducted a cohort study using the National Health Insurance reimbursement database to enroll all ESRD patients in Taiwan from 1998-2002. Cox regression models were constructed and hazard ratios and confidence intervals were estimated after controlling for potential confounders, including age, sex, residence in region with endemic black foot disease, urinary tract infection, and use of non-steroidal anti-inflammatory drugs and acetaminophen.<br />Results: A total of 38,995 ESRD patients were included in the final analysis, and 320 patients developed UC after ESRD. Having been prescribed Mu Tong that was adulterated with Guan Mu Tong (Aristolochia manshuriensis) before 2004, or an estimated consumption of more than 1-100 mg of aristolochic acid, were both associated with an increased risk of UC in the multivariable analyses. Analgesic consumption of more than 150 pills was also associated with an increased risk of UC, although there was little correlation between the two risk factors.<br />Conclusion: Consumption of aristolochic acid-related Chinese herbal products was associated with an increased risk of developing UC in ESRD patients. Regular follow-up screening for UC in ESRD patients who have consumed Chinese herbal products is thus necessary.
- Subjects :
- Aged
Aged, 80 and over
Aristolochic Acids therapeutic use
Cohort Studies
Drugs, Chinese Herbal therapeutic use
Female
Humans
Incidence
Male
Middle Aged
Risk Factors
Taiwan epidemiology
Urologic Neoplasms epidemiology
Aristolochic Acids adverse effects
Drugs, Chinese Herbal adverse effects
Kidney Failure, Chronic complications
Kidney Failure, Chronic drug therapy
Urologic Neoplasms chemically induced
Urologic Neoplasms complications
Subjects
Details
- Language :
- English
- ISSN :
- 1932-6203
- Volume :
- 9
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- PloS one
- Publication Type :
- Academic Journal
- Accession number :
- 25170766
- Full Text :
- https://doi.org/10.1371/journal.pone.0105218