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Efficacy and safety of bevacizumab in Chinese patients with metastatic colorectal cancer.
- Source :
-
Asian Pacific journal of cancer prevention : APJCP [Asian Pac J Cancer Prev] 2014; Vol. 15 (16), pp. 6559-64. - Publication Year :
- 2014
-
Abstract
- Objective: To evaluate the efficacy and safety of bevacizumab in the treatment of patients with metastatic colorectal cancer (mCRC).<br />Methods: In a single-center, observational study of 91 Chinese patients with mCRC who received bevacizumab in combination with chemotherapy was conducted. OBJECTIVE response rates (ORRs), progression-free survival (PFS), overall survival (OS) and adverse events were recorded, and the relationships between various clinical factors and PFS or OS were evaluated by Cox proportional hazards models.<br />Results: Treatment with bevacizumab and chemotherapy was effective and tolerable. Univariate analysis showed that PFS and OS were significantly associated with the Eastern Cooperative Oncology Group performance status (ECOG- PS) score, duration of bevacizumab exposure, and whether chemotherapy was continued after discontinuation of bevacizumab treatment. A multivariate analysis showed that the duration of bevacizumab exposure and whether chemotherapy was continued after discontinuation of bevacizumab were independent prognostic factors for PFS and OS.<br />Conclusion: In Chinese mCRC population, the shorter the duration of exposure to bevacizumab and chemotherapy, the worse the prognosis is.
- Subjects :
- Adult
Aged
Antineoplastic Combined Chemotherapy Protocols adverse effects
Antineoplastic Combined Chemotherapy Protocols therapeutic use
Bevacizumab
Camptothecin adverse effects
Camptothecin analogs & derivatives
Camptothecin therapeutic use
China
Colorectal Neoplasms mortality
Disease-Free Survival
Female
Fluorouracil adverse effects
Fluorouracil therapeutic use
Humans
Leucovorin adverse effects
Leucovorin therapeutic use
Male
Middle Aged
Organoplatinum Compounds adverse effects
Organoplatinum Compounds therapeutic use
Treatment Outcome
Young Adult
Angiogenesis Inhibitors adverse effects
Angiogenesis Inhibitors therapeutic use
Antibodies, Monoclonal, Humanized adverse effects
Antibodies, Monoclonal, Humanized therapeutic use
Colorectal Neoplasms drug therapy
Subjects
Details
- Language :
- English
- ISSN :
- 2476-762X
- Volume :
- 15
- Issue :
- 16
- Database :
- MEDLINE
- Journal :
- Asian Pacific journal of cancer prevention : APJCP
- Publication Type :
- Academic Journal
- Accession number :
- 25169487
- Full Text :
- https://doi.org/10.7314/apjcp.2014.15.16.6559