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The G-protein-coupled estrogen receptor (GPER/GPR30) in ovarian granulosa cell tumors.
- Source :
-
International journal of molecular sciences [Int J Mol Sci] 2014 Aug 27; Vol. 15 (9), pp. 15161-72. Date of Electronic Publication: 2014 Aug 27. - Publication Year :
- 2014
-
Abstract
- Ovarian granulosa cell tumors (GCTs) are thought to arise from cells of the ovarian follicle and comprise a rare entity of ovarian masses. We recently identified the G-protein-coupled estrogen receptor (GPER/GPR30) to be present in granulosa cells, to be regulated by gonadotropins in epithelial ovarian cancer and to be differentially expressed throughout folliculogenesis. Thus, supposing a possible role of GPER in GCTs, this study aimed to analyze GPER in GCTs. GPER immunoreactivity in GCTs (n = 26; n (primary diagnosis) = 15, n (recurrence) = 11) was studied and correlated with the main clinicopathological variables. Positive GPER staining was identified in 53.8% (14/26) of GCTs and there was no significant relation of GPER with tumor size or lymph node status. Those cases presenting with strong GPER intensity at primary diagnosis showed a significant reduced overall survival (p = 0.002). Due to the fact that GPER is regulated by estrogens, as well as gonadotropins, GPER may also be affected by endocrine therapies applied to GCT patients. Moreover, with our data supposing GPER to be associated with GCT prognosis, GPER might be considered as a possible confounder when assessing the efficacy of hormone-based therapeutic approaches in GCTs.
- Subjects :
- Adult
Aged
Biomarkers, Tumor genetics
Female
Granulosa Cell Tumor diagnosis
Humans
Middle Aged
Ovarian Neoplasms diagnosis
Prognosis
Receptors, Estrogen genetics
Receptors, G-Protein-Coupled genetics
Biomarkers, Tumor metabolism
Granulosa Cell Tumor metabolism
Ovarian Neoplasms metabolism
Receptors, Estrogen metabolism
Receptors, G-Protein-Coupled metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1422-0067
- Volume :
- 15
- Issue :
- 9
- Database :
- MEDLINE
- Journal :
- International journal of molecular sciences
- Publication Type :
- Academic Journal
- Accession number :
- 25167139
- Full Text :
- https://doi.org/10.3390/ijms150915161