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Hemodynamic effects of nifedipine tocolysis.
- Source :
-
The journal of obstetrics and gynaecology research [J Obstet Gynaecol Res] 2015 Jan; Vol. 41 (1), pp. 17-22. Date of Electronic Publication: 2014 Aug 27. - Publication Year :
- 2015
-
Abstract
- Aim: To describe the effects of nifedipine tocolysis on blood pressure and heart rate in non-hypertensive women.<br />Methods: This was a retrospective study from 2001 to 2011 to compare blood pressures and heart rates among non-hypertensive women on nifedipine tocolysis up to 8 h after nifedipine initiation. Measurements at 20-60 and 61-120 min were compared to assess the differential effects of dosing on hemodynamics and reflected the effects of the initial and complete loading doses, respectively. Charts were reviewed for hypotension-related emergent delivery.<br />Results: One hundred and thirty-eight patients were included. Over the 8-h study interval, mean systolic blood pressure (P < 0.001) and mean diastolic blood pressure (P < 0.001) decreased by 5 mmHg and heart rate increased by 4 b.p.m. (P < 0.001). Systolic and diastolic blood pressures were unchanged from baseline up to 120 min at all doses. Heart rate increased at both 20-60 and 61-120 min when all doses were considered (P < 0.001), but differential dosing effects were not observed. Rates of tachycardia increased (P < 0.001), but rates of hypotension were unchanged. No hypotension-related emergent deliveries occurred.<br />Conclusion: Nifedipine tocolysis was associated with hemodynamic changes in non-hypertensive women. Tachycardia was increased but hypotension was unaffected, supporting the general safety of nifedipine in this setting.<br /> (© 2014 The Authors. Journal of Obstetrics and Gynaecology Research © 2014 Japan Society of Obstetrics and Gynecology.)
Details
- Language :
- English
- ISSN :
- 1447-0756
- Volume :
- 41
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- The journal of obstetrics and gynaecology research
- Publication Type :
- Academic Journal
- Accession number :
- 25164435
- Full Text :
- https://doi.org/10.1111/jog.12478