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Intra-articular injection of tranexamic acid to reduce blood loss after total knee arthroplasty.
- Source :
-
Journal of orthopaedic surgery (Hong Kong) [J Orthop Surg (Hong Kong)] 2014 Aug; Vol. 22 (2), pp. 146-9. - Publication Year :
- 2014
-
Abstract
- Purpose: To evaluate the effect of intra-articular tranexamic acid (TXA) on blood loss after total knee arthroplasty (TKA).<br />Methods: Medical records of 73 men and 93 women (mean age, 68 years) who underwent primary TKA for osteoarthritis and received intra-articular TXA 1500 mg (n=56) or 3000 mg (n=56) or not at all (n=54) were reviewed. Reduction in haemoglobin levels on days 1 and 2 was measured, as were the rates of venous thromboembolism (VTE) and blood transfusion.<br />Results: Reduction in haemoglobin levels on day 2 was significantly greater in controls (35 ± 11 g/dl) than the 1500 mg TXA group (29 ± 9 g/dl, p=0.005) and the 3000 mg TXA group (23 ± 10 g/dl, p<0.001). The difference between the 2 TXA groups was also significant (p=0.002). There was a dose-dependent effect of TXA on blood loss. The rates of VTE and blood transfusion did not differ significantly between groups.<br />Conclusion: Intra-articular administration of TXA is effective in reducing blood loss after TKA, without increasing the risk of VTE.
- Subjects :
- Aged
Blood Transfusion
Dose-Response Relationship, Drug
Female
Hemoglobins metabolism
Humans
Injections, Intra-Articular
Male
Middle Aged
Postoperative Hemorrhage etiology
Retrospective Studies
Venous Thromboembolism epidemiology
Antifibrinolytic Agents administration & dosage
Arthroplasty, Replacement, Knee adverse effects
Osteoarthritis, Knee surgery
Postoperative Hemorrhage prevention & control
Tranexamic Acid administration & dosage
Subjects
Details
- Language :
- English
- ISSN :
- 2309-4990
- Volume :
- 22
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Journal of orthopaedic surgery (Hong Kong)
- Publication Type :
- Academic Journal
- Accession number :
- 25163943
- Full Text :
- https://doi.org/10.1177/230949901402200205