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Synthesis and antitumor activity of feruloyl and caffeoyl derivatives.
- Source :
-
Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2014 Sep 15; Vol. 24 (18), pp. 4367-4371. Date of Electronic Publication: 2014 Aug 18. - Publication Year :
- 2014
-
Abstract
- We developed two efficient protocols for the synthesis of feruloyl and caffeoyl derivatives from commercial vanillin and veratraldehyde. Pharmacological activities were assessed against a panel of human cancer cell lines in vitro. Most synthesized compounds demonstrated attractive cytotoxicity. Several new compounds demonstrated significant antiproliferative and cytotoxic activities against HeLa and Bewo tumor cell lines. In particular, 5-nitro caffeic adamantyl ester showed broad spectrum of tumor inhibition in 10 cell lines, and reduced tumor weight by 36.7% in vivo when administered at a dose of 40 mg kg(-1).<br /> (Copyright © 2014 Elsevier Ltd. All rights reserved.)
- Subjects :
- Antineoplastic Agents, Phytogenic chemical synthesis
Antineoplastic Agents, Phytogenic chemistry
Apoptosis drug effects
Caffeic Acids chemical synthesis
Caffeic Acids chemistry
Cell Line, Tumor
Cell Proliferation drug effects
Coumaric Acids chemical synthesis
Coumaric Acids chemistry
Dose-Response Relationship, Drug
Drug Screening Assays, Antitumor
HL-60 Cells
HeLa Cells
Hep G2 Cells
Humans
Molecular Structure
Structure-Activity Relationship
Antineoplastic Agents, Phytogenic pharmacology
Caffeic Acids pharmacology
Coumaric Acids pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 1464-3405
- Volume :
- 24
- Issue :
- 18
- Database :
- MEDLINE
- Journal :
- Bioorganic & medicinal chemistry letters
- Publication Type :
- Academic Journal
- Accession number :
- 25160837
- Full Text :
- https://doi.org/10.1016/j.bmcl.2014.08.024