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Lutein supplementation leads to decreased soluble complement membrane attack complex sC5b-9 plasma levels.
- Source :
-
Acta ophthalmologica [Acta Ophthalmol] 2015 Mar; Vol. 93 (2), pp. 141-5. Date of Electronic Publication: 2014 Aug 27. - Publication Year :
- 2015
-
Abstract
- Purpose: The purpose of this study was to investigate the effect of lutein on systemic complement activation in elderly individuals.<br />Methods: Seventy patients with signs of early age-related macular degeneration (AMD) were included in this study. All subjects were randomly assigned to receive a 10 mg daily dose of lutein or a placebo for a time period of 1 year. EDTA blood was collected before and at various time-points during the study (0, 4, 8 and 12 months). The plasma level of the soluble complement membrane attack complex sC5b-9 was measured by ELISA.<br />Results: We found a significant 1.1 ng/ml monthly decrease in the plasma sC5b-9 concentration in the lutein group (p<0.001), resulting in a decrease from 60.3 ng/ml at baseline to 46.3 ng/ml at 12 months. For the placebo group, we found a significant 0.6 ng/ml monthly increase in plasma sC5b-9 concentration (p=0.001), resulting in an increase from 51.6 ng/ml at baseline to 58.4 ng/ml at 12 months.<br />Conclusions: Lutein supplementation inhibits the systemic activation of the complement system, which provides further functional evidence for the reported beneficial effects of this carotenoid in the management of AMD.<br /> (© 2014 Acta Ophthalmologica Scandinavica Foundation. Published by John Wiley & Sons Ltd.)
- Subjects :
- Aged
Aged, 80 and over
Enzyme-Linked Immunosorbent Assay
Female
Follow-Up Studies
Humans
Macular Degeneration blood
Male
Middle Aged
Complement Activation drug effects
Complement Membrane Attack Complex metabolism
Dietary Supplements
Lutein administration & dosage
Macular Degeneration drug therapy
Subjects
Details
- Language :
- English
- ISSN :
- 1755-3768
- Volume :
- 93
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Acta ophthalmologica
- Publication Type :
- Academic Journal
- Accession number :
- 25160533
- Full Text :
- https://doi.org/10.1111/aos.12535