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MSN-mediated sequential vascular-to-cell nuclear-targeted drug delivery for efficient tumor regression.
- Source :
-
Advanced materials (Deerfield Beach, Fla.) [Adv Mater] 2014 Oct 22; Vol. 26 (39), pp. 6742-8. Date of Electronic Publication: 2014 Aug 26. - Publication Year :
- 2014
-
Abstract
- Mesoporous silica nanoparticles functionalized with peptides are developed for sequential drug delivery. The RGD peptide is used for vasculature/cell membrane targeting and the TAT peptide for nuclear targeting. Using this delivery strategy, a tumor in a murine xenograft model is successfully regressed.<br /> (© 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.)
- Subjects :
- Animals
Antineoplastic Agents chemistry
Antineoplastic Agents pharmacology
Doxorubicin chemistry
Doxorubicin metabolism
Doxorubicin pharmacology
Gene Products, tat chemistry
HeLa Cells
Humans
Mice
Oligopeptides chemistry
Porosity
Xenograft Model Antitumor Assays
Antineoplastic Agents metabolism
Blood Vessels metabolism
Cell Nucleus metabolism
Drug Carriers chemistry
Drug Carriers metabolism
Nanoparticles chemistry
Silicon Dioxide chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 1521-4095
- Volume :
- 26
- Issue :
- 39
- Database :
- MEDLINE
- Journal :
- Advanced materials (Deerfield Beach, Fla.)
- Publication Type :
- Academic Journal
- Accession number :
- 25159109
- Full Text :
- https://doi.org/10.1002/adma.201402752