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Wharton's jelly mesenchymal stem cells promote wound healing and tissue regeneration.

Authors :
Kamolz LP
Keck M
Kasper C
Source :
Stem cell research & therapy [Stem Cell Res Ther] 2014 May 02; Vol. 5 (3), pp. 62. Date of Electronic Publication: 2014 May 02.
Publication Year :
2014

Abstract

Wound healing requires an orchestrated integration of complex biological and molecular events, which include inflammation, proliferation and remodeling. Wharton's jelly mesenchymal stem cells seem to promote wound healing and tissue repair. Wharton's jelly stem cells promote fibroblast proliferation and migration, accelerate re-epithelialization and promote overall wound repair by pcrine signaling. Wharton's jelly is an advantageous mesenchymal stem cell source because the harvest of this type of stem cells is not painful or invasive and because, beside their effect on wound healing, they seem to have a significant impact on the treatment of keloids. Furthermore, they led to better nerve regeneration, better neuroprotection and less inflammation.

Details

Language :
English
ISSN :
1757-6512
Volume :
5
Issue :
3
Database :
MEDLINE
Journal :
Stem cell research & therapy
Publication Type :
Academic Journal
Accession number :
25157597
Full Text :
https://doi.org/10.1186/scrt451