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Synthesis, characterization and in vitro anticancer activity of C-5 curcumin analogues with potential to inhibit TNF-α-induced NF-κB activation.
- Source :
-
BioMed research international [Biomed Res Int] 2014; Vol. 2014, pp. 524161. Date of Electronic Publication: 2014 Jul 24. - Publication Year :
- 2014
-
Abstract
- In a search of new compounds active against cancer, synthesis of a series of C-5 curcumin analogues was carried out. The new compounds demonstrated good cytotoxicity against chronic myeloid leukemia (KBM5) and colon cancer (HCT116) cell lines. Further, these compounds were found to have better potential to inhibit TNF-α-induced NF-κB activation in comparison to curcumin, which show their potential to act as anti-inflammatory agents. Some compounds were found to show higher cytotoxicity against cancer cell lines in comparison to curcumin used as standard.
- Subjects :
- Anti-Inflammatory Agents pharmacology
Antineoplastic Agents chemistry
Antineoplastic Agents pharmacology
Cell Death drug effects
Cell Line, Tumor
Curcumin chemistry
Curcumin pharmacology
Down-Regulation drug effects
Electrophoretic Mobility Shift Assay
Humans
Antineoplastic Agents chemical synthesis
Curcumin analogs & derivatives
Curcumin chemical synthesis
NF-kappa B metabolism
Tumor Necrosis Factor-alpha pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 2314-6141
- Volume :
- 2014
- Database :
- MEDLINE
- Journal :
- BioMed research international
- Publication Type :
- Academic Journal
- Accession number :
- 25157362
- Full Text :
- https://doi.org/10.1155/2014/524161