Covalent bond or noncovalent bond: a supramolecular strategy for the construction of chemically synthesized vaccines.

Authors :: Gao Y
Sun ZY
Huang ZH
Chen PG
Chen YX
Zhao YF
Li YM
Source :: Chemistry (Weinheim an der Bergstrasse, Germany) [Chemistry] 2014 Oct 13; Vol. 20 (42), pp. 13541-6. Date of Electronic Publication: 2014 Aug 25.
Publication Year :: 2014
Abstract: A novel noncovalent strategy to construct chemically synthesized vaccines has been designed to trigger a robust immune response and to dramatically improve the efficiency of vaccine preparation. Glycosylated MUC1 tripartite vaccines were constructed through host-guest interactions with cucurbit[8]uril. These vaccines elicited high levels of IgG antibodies that were recognized by transformed cells and induced the secretion of cytokines. The antisera also mediated complement-dependent cytotoxicity. This noncovalent strategy with good suitability, scalability, and feasibility can be applied as a universal strategy for the construction of chemically synthesized vaccines.<br /> (© 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.)

Subjects :: Animals
Cancer Vaccines immunology
Cell Line, Tumor
Female
Glycosylation
Humans
Mice, Inbred BALB C
Mucin-1 immunology
Neoplasms immunology
Neoplasms prevention & control
Vaccines, Synthetic immunology
Bridged-Ring Compounds chemistry
Cancer Vaccines chemistry
Imidazoles chemistry
Mucin-1 chemistry
Vaccines, Synthetic chemistry

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