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Effect of growth hormone deficiency on brain MRI findings among children with growth restrictions.
- Source :
-
Journal of pediatric endocrinology & metabolism : JPEM [J Pediatr Endocrinol Metab] 2015 Jan; Vol. 28 (1-2), pp. 117-23. - Publication Year :
- 2015
-
Abstract
- Objectives: Growth hormone deficiency (GHD) is a major problem among children with short stature. In this study, the role of brain magnetic resonance imaging (MRI) in defining the underlying defects among short children with GHD is evaluated.<br />Methods: In a cross-sectional study, data of 158 children were evaluated. Growth hormone (GH) levels were measured using stimulating tests and brain MRI with gadolinium contrast was applied, as well.<br />Results: Some 25.3% of patients had GHD with a mean age of 8.01±3.40 years. MRI results showed 35 as normal, four with pituitary hypoplasia, and one with microadenoma. The MRI results were significantly associated with GH levels and presence of other endocrine disorders. There was a significant association between prenatal disorders and patients' bone age delay.<br />Conclusions: In patients with severe GHD and patients with multiple pituitary hormone deficiencies, MRI is more likely to be abnormal, and bone age is much delayed in patients with history of prenatal disorders.
- Subjects :
- Adolescent
Age Determination by Skeleton
Body Height
Body Weight
Child
Child, Preschool
Cross-Sectional Studies
Dwarfism, Pituitary complications
Dwarfism, Pituitary diagnosis
Female
Growth Disorders complications
Growth Disorders diagnosis
Humans
Hypopituitarism complications
Hypopituitarism diagnosis
Male
Brain pathology
Dwarfism, Pituitary pathology
Growth Disorders pathology
Human Growth Hormone deficiency
Hypopituitarism pathology
Magnetic Resonance Imaging
Subjects
Details
- Language :
- English
- ISSN :
- 2191-0251
- Volume :
- 28
- Issue :
- 1-2
- Database :
- MEDLINE
- Journal :
- Journal of pediatric endocrinology & metabolism : JPEM
- Publication Type :
- Academic Journal
- Accession number :
- 25153566
- Full Text :
- https://doi.org/10.1515/jpem-2013-0294