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Clinical and endoscopic characteristics of drug-induced esophagitis.
- Source :
-
World journal of gastroenterology [World J Gastroenterol] 2014 Aug 21; Vol. 20 (31), pp. 10994-9. - Publication Year :
- 2014
-
Abstract
- Aim: To investigate clinical, endoscopic and pathological characteristics of drug-induced esophagitis.<br />Methods: Data for patients diagnosed with drug-induced esophagitis from April 2002 to May 2013 was reviewed. Patients diagnosed with malignancy, viral or fungal esophagitis were excluded. Clinical, endoscopic and pathological characteristics of patients diagnosed with drug-induced esophagitis were analyzed.<br />Results: Seventy-eight patients were diagnosed with drug-induced esophagitis. Their mean age was 43.9 ± 18.9 years and 35.9% were male. Common symptoms were chest pain (71.8%), odynophagia (38.5%) and dysphagia (29.5%). The endoscopic location was in the middle third of esophagus in 78.2%. Endoscopic findings were ulcer (82.1%), erosion (17.9%), ulcer with bleeding (24.4%), coating with drug material (5.1%), impacted pill fragments (3.8%) and stricture (2.6%). Kissing ulcers were observed in 43.6%. The main causative agents were antibiotics and non-steroidal anti-inflammatory drugs. All the patients were treated with proton pump inhibitors (PPIs) or sucralfate, and the causative drugs were discontinued. Nineteen patients with drug-induced esophagitis were followed up with endoscopy and revealed normal findings, scars or healing ulcers.<br />Conclusion: Drug-induced esophagitis mainly presents as chest pain, odynophagia and dysphagia, and may be successfully treated with PPIs and discontinuation of the causative drug. Kissing ulcers were observed in 43.6%.
- Subjects :
- Adolescent
Adult
Aged
Aged, 80 and over
Anti-Ulcer Agents therapeutic use
Chest Pain chemically induced
Deglutition Disorders chemically induced
Esophageal Stenosis chemically induced
Esophageal Stenosis pathology
Esophagitis drug therapy
Female
Gastrointestinal Hemorrhage chemically induced
Gastrointestinal Hemorrhage pathology
Humans
Male
Middle Aged
Predictive Value of Tests
Proton Pump Inhibitors therapeutic use
Republic of Korea
Retrospective Studies
Risk Factors
Sucralfate therapeutic use
Time Factors
Treatment Outcome
Ulcer chemically induced
Ulcer pathology
Wound Healing
Young Adult
Anti-Bacterial Agents adverse effects
Anti-Inflammatory Agents, Non-Steroidal adverse effects
Esophagitis chemically induced
Esophagitis pathology
Esophagoscopy
Esophagus drug effects
Esophagus pathology
Subjects
Details
- Language :
- English
- ISSN :
- 2219-2840
- Volume :
- 20
- Issue :
- 31
- Database :
- MEDLINE
- Journal :
- World journal of gastroenterology
- Publication Type :
- Academic Journal
- Accession number :
- 25152603
- Full Text :
- https://doi.org/10.3748/wjg.v20.i31.10994