Steroidal glycosides from the underground parts of Dracaena thalioides and their cytotoxic activity.

Authors :: Tang L
Wang Z
Wu H
Yokosuka A
Mimaki Y
Source :: Phytochemistry [Phytochemistry] 2014 Nov; Vol. 107, pp. 102-10. Date of Electronic Publication: 2014 Aug 21.
Publication Year :: 2014
Abstract: Six spirostanol glycosides (1-6) and 12 known compounds (7-18) were isolated from the underground parts of Dracaena thalioides (Agavaceae). Their structures were determined by spectroscopic analysis, including 2D NMR spectroscopic data, and chemical transformations. The isolated compounds were evaluated for cytotoxic activity against HL-60 human leukemia cells. Compounds 1, 3-6, and 8-18 showed cytotoxicity against HL-60 cells, of which 10, a bisdesmosidic spirostanol derivative, showed potent cytotoxicity against HL-60 cells with an IC50 value of 0.38μM and induced apoptosis in HL-60 cells.<br /> (Copyright © 2014 Elsevier Ltd. All rights reserved.)

Subjects :: Antineoplastic Agents, Phytogenic chemistry
Apoptosis drug effects
Drug Screening Assays, Antitumor
Glycosides chemistry
HL-60 Cells
Humans
Japan
Molecular Structure
Nuclear Magnetic Resonance, Biomolecular
Spirostans chemistry
Antineoplastic Agents, Phytogenic isolation & purification
Antineoplastic Agents, Phytogenic pharmacology
Dracaena chemistry
Glycosides isolation & purification
Glycosides pharmacology
Spirostans isolation & purification
Spirostans pharmacology

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