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Effects of age-related loss of P/Q-type calcium channels in a mice model of peripheral nerve injury.
- Source :
-
Neurobiology of aging [Neurobiol Aging] 2015 Jan; Vol. 36 (1), pp. 352-64. Date of Electronic Publication: 2014 Jul 25. - Publication Year :
- 2015
-
Abstract
- We analyzed the role of P/Q-type calcium channels in sciatic nerve regeneration after lesion induced by chronic constriction injury (CCI) in heterozygous null mutant mice lacking the CaV2.1α1 subunit of these channels (Cacna1a+/-). Compared with wild type, Cacna1a+/- mice showed an initial reduction of the CCI-induced allodynia, indicating a reduced pain perception, but they also evidenced a lack of recovery over time, with atrophy of the injured hindpaw still present 3 months after CCI when wild-type mice fully recovered. In parallel, Cacna1a+/- mice exhibited an early onset of age-dependent loss of P/Q-type channels, which can be responsible for the lack of functional recovery. Moreover, Cacna1a+/- mice showed an early age-dependent reduction of muscular strength, as well as of Schwann cells proliferation and sciatic nerve remyelination. This study demonstrates the important role played by P/Q-type channels in recovery from nerve injury and has important implications for the knowledge of age-related processes.<br /> (Copyright © 2015 Elsevier Inc. All rights reserved.)
- Subjects :
- Animals
Calcium Channels, P-Type physiology
Calcium Channels, Q-Type physiology
Disease Models, Animal
Mice, Inbred Strains
Nerve Regeneration physiology
Peripheral Nerve Injuries physiopathology
Sciatic Nerve metabolism
Sciatic Nerve physiology
Aging metabolism
Calcium Channels, P-Type deficiency
Calcium Channels, P-Type metabolism
Calcium Channels, Q-Type deficiency
Peripheral Nerve Injuries metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1558-1497
- Volume :
- 36
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Neurobiology of aging
- Publication Type :
- Academic Journal
- Accession number :
- 25150573
- Full Text :
- https://doi.org/10.1016/j.neurobiolaging.2014.07.025