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Subcutaneous phaeohyphomycosis in a patient with IgG4-related sclerosing disease caused by a novel ascomycete, Hongkongmyces pedis gen. et sp. nov.: first report of human infection associated with the family Lindgomycetaceae.
- Source :
-
Medical mycology [Med Mycol] 2014 Oct; Vol. 52 (7), pp. 736-47. Date of Electronic Publication: 2014 Aug 20. - Publication Year :
- 2014
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Abstract
- No members of the freshwater ascomycetes family Lindgomycetaceae have been associated with human infections. We isolated a mould (HKU35(T)) from the biopsy specimen of a patient with invasive foot infection and underlying immunoglobulin G4-related sclerosing disease. Histology showed florid, suppurative, granulomatous inflammation in the dermis, with central microabscess formation surrounded by epithelioid histiocytes, scattered giant cells, and a small number of lymphocytes. A Grocott stain revealed fungal elements in the center of the lesion. On Sabouraud glucose agar, HKU35(T) grew as gray and velvety colonies. Among the members of the family Lindgomycetaceae, HKU35(T) was the only strain that grew at 37°C. Microscopically, only sterile mycelia, but no fruiting bodies, were observed. HKU35(T) was susceptible to itrazonazole, voriconazole, and posaconazole, which was in line with the patient's clinical response to itraconazole treatment. Internal transcribed spacer and partial 18S nuclear rDNA (nrDNA), 28S nrDNA, β-tubulin gene, and EF1α gene sequencing showed that HKU35(T) occupied a unique phylogenetic position, most closely related to but distinct from members of the genera Clohesyomyces and Lindgomyces. We propose a new genus and species, Hongkongmyces pedis gen. et sp. nov., to describe this fungus, which belongs to the family Lindgomycetaceae in the orderPleosporales of class Dothideomycetes. This case also represents the first report of human infection associated with the family Lindgomycetaceae.<br /> (© The Author 2014. Published by Oxford University Press on behalf of The International Society for Human and Animal Mycology. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.)
- Subjects :
- Aged
Antifungal Agents pharmacology
Ascomycota drug effects
Ascomycota genetics
Cluster Analysis
DNA, Fungal chemistry
DNA, Fungal genetics
DNA, Ribosomal chemistry
DNA, Ribosomal genetics
DNA, Ribosomal Spacer chemistry
DNA, Ribosomal Spacer genetics
Foot pathology
Histocytochemistry
Humans
Immune System Diseases complications
Male
Microbial Sensitivity Tests
Microbiological Techniques
Microscopy
Molecular Sequence Data
Phaeohyphomycosis pathology
Phylogeny
RNA, Ribosomal, 18S genetics
RNA, Ribosomal, 28S genetics
Sequence Analysis, DNA
Tubulin genetics
Ascomycota classification
Ascomycota isolation & purification
Phaeohyphomycosis diagnosis
Phaeohyphomycosis microbiology
Subjects
Details
- Language :
- English
- ISSN :
- 1460-2709
- Volume :
- 52
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- Medical mycology
- Publication Type :
- Academic Journal
- Accession number :
- 25147085
- Full Text :
- https://doi.org/10.1093/mmy/myu043