The activity of silver nanoparticles (Axonnite) on clinical and environmental strains of Acinetobacter spp.

Authors :: Łysakowska ME
Ciebiada-Adamiec A
Klimek L
Sienkiewicz M
Source :: Burns : journal of the International Society for Burn Injuries [Burns] 2015 Mar; Vol. 41 (2), pp. 364-71. Date of Electronic Publication: 2014 Aug 18.
Publication Year :: 2015
Abstract: Acinetobacter baumannii isolates are responsible for a high number of wound infections. The reason of this study was to evaluate the activity of silver nanoparticles obtained by microexplosion against wide range of Acinetobacter spp. Susceptibility to silver nanoparticles was tested by microdilution method, susceptibility to antibiotics was evaluated by the disc-diffusion method. All strains of Acinetobacter spp. were sensitive to AgNPs at low concentrations. The values of the MIC for strains of Acinetobacter spp. were 0.39 and 0.78μg/mL. In general, strains inhibited by 0.78μg/mL of AgNPs were more resistant to antibiotics than Acinetobacter strains for which MIC=0.39μg/mL (p=0.023). The AgNPs in Axonnite seems to be a good alternative for other antimicrobials to treat wound infections caused by multidrug resistant Acinetobacter spp. strains because of its high activity.<br /> (Copyright © 2014 Elsevier Ltd and ISBI. All rights reserved.)

Subjects :: Acinetobacter Infections prevention & control
Anti-Bacterial Agents chemistry
Drug Resistance, Multiple, Bacterial drug effects
Humans
Microbial Sensitivity Tests
Acinetobacter drug effects
Anti-Bacterial Agents pharmacology
Metal Nanoparticles chemistry
Silver pharmacology

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