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Neurocognitive outcomes in pediatric diabetes: a developmental perspective.
Neurocognitive outcomes in pediatric diabetes: a developmental perspective.
- Source :
-
Current diabetes reports [Curr Diab Rep] 2014 Oct; Vol. 14 (10), pp. 533. - Publication Year :
- 2014
-
Abstract
- The impact of diabetes on the developing brain is well-accepted. Effects on neurocognitive functioning are moderate but have larger functional implications, especially when considered through a developmental lens. Pathophysiological factors such as severe hypoglycemia and chronic hyperglycemia can alter developmental trajectories in early childhood and perhaps at later periods. In this paper, we selectively review neurocognitive outcomes in pediatric diabetes (largely type 1), integrating recent research from developmental neuroscience and neuroimaging. We examine the effects of diabetes at different stages and place findings within a neurodevelopmental diathesis/stress framework. Early-onset diabetes is associated with specific effects on memory and more global cognitive late-effects, but less is known about cognitive outcomes of diabetes in later childhood and in adolescence, a time of increased neurobehavioral vulnerability that has received relatively limited empirical attention. Studies are also needed to better elucidate risk and protective factors that may moderate neurodevelopmental outcomes in youth with diabetes.
- Subjects :
- Adolescent
Age of Onset
Child
Diabetes Mellitus, Type 1 blood
Diabetes Mellitus, Type 1 complications
Educational Measurement
Humans
Hyperglycemia physiopathology
Hyperglycemia psychology
Hypoglycemia physiopathology
Hypoglycemia psychology
Risk Factors
Stress, Psychological physiopathology
Stress, Psychological psychology
Young Adult
Child Development
Diabetes Mellitus, Type 1 physiopathology
Diabetes Mellitus, Type 1 psychology
Neuroimaging methods
Stress, Psychological etiology
Subjects
Details
- Language :
- English
- ISSN :
- 1539-0829
- Volume :
- 14
- Issue :
- 10
- Database :
- MEDLINE
- Journal :
- Current diabetes reports
- Publication Type :
- Academic Journal
- Accession number :
- 25142718
- Full Text :
- https://doi.org/10.1007/s11892-014-0533-x