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An oxidation-labile traceless linker for solid-phase synthesis.
- Source :
-
Angewandte Chemie (International ed. in English) [Angew Chem Int Ed Engl] 1999; Vol. 38 (8), pp. 1073-7. - Publication Year :
- 1999
-
Abstract
- Traceless release of biaryls, acetylenes, alkenes, heterocycles, thioethers, and secondary amines from different solid supports can be achieved under very mild conditions by using a hydrazide group. This group, which is converted into an acyl diazene by oxidation and subsequently cleaved by a nucleophile (see scheme), is thus an attractive new linker for solid-phase synthesis and combinatorial chemistry.<br /> (Copyright © 1999 WILEY-VCH Verlag GmbH, Weinheim, Fed. Rep. of Germany.)
Details
- Language :
- English
- ISSN :
- 1433-7851
- Volume :
- 38
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- Angewandte Chemie (International ed. in English)
- Publication Type :
- Academic Journal
- Accession number :
- 25138498
- Full Text :
- https://doi.org/10.1002/(SICI)1521-3773(19990419)38:8<1073::AID-ANIE1073>3.0.CO;2-Y