One minute ultraviolet exposure inhibits Toxoplasma gondii tachyzoite replication and cyst conversion without diminishing host humoral-mediated immune response.

Authors :: Kannan G
Prandovszky E
Steinfeldt CB
Gressitt KL
Yang C
Yolken RH
Severance EG
Jones-Brando L
Pletnikov MV
Source :: Experimental parasitology [Exp Parasitol] 2014 Oct; Vol. 145, pp. 110-7. Date of Electronic Publication: 2014 Aug 14.
Publication Year :: 2014
Abstract: We developed a protocol to inactivate Toxoplasma gondii (T. gondii) tachyzoites employing 1 min of ultraviolet (UV) exposure. We show that this treatment completely inhibited parasite replication and cyst formation in vitro and in vivo but did not affect the induction of a robust IgG response in mice. We propose that our protocol can be used to study the contribution of the humoral immune response to rodent behavioral alterations following T. gondii infection.<br /> (Copyright © 2014 Elsevier Inc. All rights reserved.)

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