Back to Search
Start Over
Quantification and genotyping of lipoprotein lipase in patients with diabetic lipaemia.
- Source :
-
Diabetic medicine : a journal of the British Diabetic Association [Diabet Med] 2014 Dec; Vol. 31 (12), pp. 1702-7. Date of Electronic Publication: 2014 Sep 17. - Publication Year :
- 2014
-
Abstract
- Aims: To determine if diabetic lipaemia is caused by loss of function mutations in the lipoprotein lipase gene, LPL.<br />Methods: We conducted a case-control study over 2 years in two tertiary care hospitals in South Australia. Six patients with a history of diabetic lipaemia and 12 control subjects, with previous diabetic ketoacidosis and peak triglyceride concentrations < 2.4 mmol/l were included. Participants were well at the time of study investigations.<br />Results: Only one patient with lipaemia had a loss of function mutation in LPL and no functional mutations in APOC2 or GPIHBP1 were identified. The mean lipoprotein lipase concentration was lower in patients with diabetic lipaemia than in control subjects (306 vs. 484 μg/l, P = 0.04). The mean fasting C-peptide concentration was higher in patients with diabetic lipaemia than in control subjects (771 vs. 50 pmol/l; P = 0.001).<br />Conclusions: Lipoprotein lipase deficiency in patients with a history of diabetic lipaemia was predominantly quantitative, rather than secondary to mutations in LPL, APOC2 or GPIHBP1. The majority of patients with severe hypertriglyceridaemia in diabetic ketoacidosis may have ketosis-prone Type 2, rather than Type 1, diabetes.<br /> (© 2014 The Authors. Diabetic Medicine © 2014 Diabetes UK.)
- Subjects :
- Adult
Aged
Apolipoprotein C-II genetics
Case-Control Studies
Cholesterol, HDL metabolism
Diabetes Mellitus, Type 1 complications
Diabetes Mellitus, Type 2 complications
Diabetic Ketoacidosis metabolism
Female
Genotype
Humans
Hyperlipidemias etiology
Hyperlipidemias metabolism
Hypertriglyceridemia etiology
Hypertriglyceridemia genetics
Hypertriglyceridemia metabolism
Lipoprotein Lipase metabolism
Male
Middle Aged
Mutation
Receptors, Lipoprotein genetics
Retrospective Studies
Young Adult
Diabetes Mellitus, Type 1 metabolism
Diabetes Mellitus, Type 2 metabolism
Hyperlipidemias genetics
Lipoprotein Lipase genetics
Subjects
Details
- Language :
- English
- ISSN :
- 1464-5491
- Volume :
- 31
- Issue :
- 12
- Database :
- MEDLINE
- Journal :
- Diabetic medicine : a journal of the British Diabetic Association
- Publication Type :
- Academic Journal
- Accession number :
- 25131724
- Full Text :
- https://doi.org/10.1111/dme.12565