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Primary cutaneous anaplastic large cell lymphomas with 6p25.3 rearrangement exhibit particular histological features.
- Source :
-
Histopathology [Histopathology] 2015 May; Vol. 66 (6), pp. 846-55. Date of Electronic Publication: 2015 Feb 04. - Publication Year :
- 2015
-
Abstract
- Aims: CD30-positive primary cutaneous lymphoproliferative disorders include several entities with differing clinical presentation but overlapping histological features, including lymphomatoid papulosis and primary cutaneous anaplastic large cell lymphoma (C-ALCL). DUSP22-IRF4 locus translocation is present in 20-57% of C-ALCLs, and has also been described in a series of 11 lymphomatoid papulosis patients, where it was associated with a particular biphasic histological pattern, including pagetoid reticulosis-type epidermal infiltration. We aimed to study whether the presence of this translocation may define distinctive histological features in C-ALCL.<br />Methods and Results: We collected three cases of C-ALCL with histological features similar to those described in the new variant of lymphomatoid papulosis with 6p25.3 rearrangement. We studied their histological features and immunophenotype, using a panel of antibodies against CD30, TCR-βF1, TCR-γ, CD4, CD8, CD20, Ki-67 and ALK. FISH analyses were performed using an IRF4-DUSP22 break-apart probe for the study of the 6p25.3 rearrangement. FISH results were positive in the three cases, which all showed distinctive histological and immunohistochemical features: a diffuse dermal infiltrate of atypical medium-to-large cells, and marked epidermotrophism with small, atypical intra-epidermal lymphocytes.<br />Conclusions: Our findings suggest that the presence of 6p25.3 rearrangement might be related to this particular biphasic pattern.<br /> (© 2014 John Wiley & Sons Ltd.)
- Subjects :
- Aged
Female
Humans
Immunophenotyping
In Situ Hybridization, Fluorescence
Male
Middle Aged
Chromosomes, Human, Pair 6 genetics
Gene Rearrangement
Lymphoma, Primary Cutaneous Anaplastic Large Cell genetics
Lymphoma, Primary Cutaneous Anaplastic Large Cell pathology
Skin Neoplasms genetics
Skin Neoplasms pathology
Subjects
Details
- Language :
- English
- ISSN :
- 1365-2559
- Volume :
- 66
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Histopathology
- Publication Type :
- Academic Journal
- Accession number :
- 25131361
- Full Text :
- https://doi.org/10.1111/his.12529