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Pharmacokinetics of oral chlortetracycline in nonpregnant adult ewes.
- Source :
-
Journal of veterinary pharmacology and therapeutics [J Vet Pharmacol Ther] 2014 Dec; Vol. 37 (6), pp. 607-10. Date of Electronic Publication: 2014 Jul 31. - Publication Year :
- 2014
-
Abstract
- The objectives of this study were to determine plasma concentrations and pharmacokinetic parameters of feed-grade chlortetracycline (CTC) in sheep after oral administration of 80 or 500 mg/head daily, divided into two equal doses given at 12-h intervals for 8 days. These are the approved, and commonly used but unapproved, feed additive doses, respectively, in the United States for the prevention of ovine infectious abortion. Blood samples were collected just prior to dosing at 0, 12, 24, 72, 96, and 192 h, as well as 4, 8, 12, 24, and 36 h after the last dose, and noncompartmental pharmacokinetic analysis was performed to estimate elimination half-life and area under the plasma concentration-time curve (AUC). Mean observed maximum CTC concentrations (Cmax ) were 20.0 ng/mL (80 mg dose) and 101 ng/mL (500 mg dose). Mean apparent elimination half-life was 18 h (80 mg dose) and 20 h (500 mg dose). Although published data do not exist to estimate plasma CTC concentrations necessary for the prevention of ovine infectious abortion, concentrations reached in our study suggest that either the FDA-approved and FDA-unapproved dosages are not high enough or that the pharmacodynamic parameter relating preventive dose to pathogen minimum inhibitory concentrations is yet to be determined.<br /> (© 2014 John Wiley & Sons Ltd.)
- Subjects :
- Abortion, Septic prevention & control
Abortion, Septic veterinary
Administration, Oral
Animals
Anti-Bacterial Agents administration & dosage
Anti-Bacterial Agents blood
Chlortetracycline administration & dosage
Chlortetracycline blood
Female
Pregnancy
Sheep blood
Sheep Diseases drug therapy
Sheep Diseases prevention & control
Anti-Bacterial Agents pharmacokinetics
Chlortetracycline pharmacokinetics
Sheep metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1365-2885
- Volume :
- 37
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Journal of veterinary pharmacology and therapeutics
- Publication Type :
- Academic Journal
- Accession number :
- 25131164
- Full Text :
- https://doi.org/10.1111/jvp.12144